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In pancreatic beta cells, the same cAMP pathway enhances glucose-stimulated insulin secretion

Hand-searching of reference lists on key papers and web-based search of the grey literature, such as Google Scholar and professional and government websites were performed with the same terms used for the published articles

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These structural modifications collectively reduce its affinity for IGF-binding proteins (IGFBPs) and extend its functional half-life to approximately 2030 hours in preclinical models, compared to 1215 hours for native IGF-1