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Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice

The truth is, because microdosing is largely experimental and not authorized by the FDA or drug manufacturers, there are no established guidelines

While full GLP-1R agonism drives the majority of GI side effects (nausea, vomiting), the partial agonism at GLP-1R combined with GIPR-mediated complementary effects may achieve greater overall efficacy with proportionally less GI distress [7]

Certain groups already face higher baseline risk for NAION, regardless of GLP-1 use: Adults over age 50

Larger, longer-duration RCTs with standardized biomarker timing and dosing are needed to clarify its clinical relevance