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"IMU-856's target, SIRT6, is highly expressed in cells of the bowel wall, including enteroendocrine cells, which produce gastrointestinal hormones such as GLP-1 and gastric inhibitory peptide (GIP)
Additionally, semaglutide slows gastric emptying, which theoretically could affect the absorption timing of oral medications, though this has not been shown to significantly impact antibiotic effectiveness in clinical practice
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AJNR Am J Neuroradiol 39:5462
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