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Most chronic wounds are characterized by a prolonged or excessive inflammatory phase, marked by an overabundant infiltration of neutrophils, persistent infections, frequent formation of atypical tissue and organ biofilms, and the inability of dermal or epidermal cells to respond to reparative stimuli

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[26], in a randomized controlled trial (RCT), analyzed the effects of LR-PRP and LP-PRP infiltration by comparing them with saline