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This is particularly disappointing because, despite being a copper peptide isolate serum with the fewest key ingredients, NIODs product comes in second for the highest cost per mL (Allies of Skins serum comes in first, but closes the gap a bit when the subscription price is lowered after the fifth order)

doi: 10.1289/ehp.1103582 131 RudelRAGrayJMEngelCLRawsthorneTWDodsonREAckermanJMet al

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Under constant exposure, receptors are pulled off the cell surface and become less responsive over time (receptor desensitization). Higher doses maintain more signal against that fade