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These active forms are crucial cofactors for enzymes involved in DNA synthesis, fatty acid metabolism, and amino acid metabolism

This effect is identical to the one observed after RYGB surgery

Uses Cancer treatment (high doses): Leukemia Lymphomas Breast, head & neck cancers Choriocarcinoma Autoimmune & inflammatory conditions (low doses): Rheumatoid arthritis (RA) Psoriasis & psoriatic arthritis Systemic lupus erythematosus (SLE) Crohns disease & ulcerative colitis Juvenile idiopathic arthritis Mechanism of Action Inhibits dihydrofolate reductase (DHFR) prevents folic acid conversion to tetrahydrofolate blocks DNA, RNA, and protein synthesis

[DOI] [PubMed] [Google Scholar] [172].Skyler JS, Bakris GL, Bonifacio E, Darsow T, Eckel RH, Groop L, Groop PH, Handelsman Y, Insel RA, Mathieu C, McElvaine AT, Palmer JP, Pugliese A, Schatz DA, Sosenko JM, Wilding JP, Ratner RE, Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis, Diabetes, 66 (2017) 241255

10.1146/annurev.physiol.010908.163221 121 StengelA.TachY