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Working solutions should be prepared fresh immediately before use or stabilized with EDTA (to chelate trace metals that catalyze oxidation) and stored at 4C for a maximum of 24 hours

Patients often feel stronger, more confident, and more motivated when exercise is part of their plan

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To evaluate this hypothesis, a Central Composite Design (CCD)-based optimization approach was used to develop a formulation with high entrapment efficiency and a particle size below 300 nm, a range considered suitable for skin delivery while limiting systemic translocation

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