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Key ingredients: Hydroquinone: A skin-lightening agent Retinoids: Derivatives of vitamin A that promote skin renewal Corticosteroids: Anti-inflammatory agents Chemical Peels Chemical peels involve applying a solution to remove the top skin layers

In recent years, mass spectrometry-based quantification methodsboth label-based and label-freehave become essential tools in proteomics

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Moreover, intersections between upregulated DEGs in the control group and downregulated DEGs in the treatment groups, as well as between downregulated DEGs in the control group and upregulated DEGs in the treatment groups, also demonstrated that the combination group had a greater overlap with the control group than either single-drug group did (Additional file 2: Figure S5)

By contrast, no significant changes in 4HNE levels were observed across groups, indicating selective modulation of oxidative stress markers [2]