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However, in people with type 2 diabetes, GIP does not contribute at all to the total insulin secretion effect of the combination while the insulinotropic effect of GLP-1 is only slightly impaired

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This is mediated through vasodilation and increased carotid artery intima-media thickness in both men and women, making these two factors predictors of atherosclerosis (35)

These theories have not been substantiated through peer-reviewed research or randomised controlled trials meeting modern scientific standards

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