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In fact, they are often taken together because they work in different ways to provide better pain relief than either medicine alone

GLP-1 also helps reduce appetite and food intake, leading to weight loss

29 , Aebi 30 , Nishikimi et al

When to talk to a doctor Eapen, MD advises, Talk to your doctor if you cannot get relief from constipation from these methods, if constipation lasts over two weeks, you feel pain, or if you see blood in your stool. Your doctor may ask you to take over-the-counter fiber supplements, magnesium, or even stool softeners and laxatives like MiraLAX to gain some short-term relief. If these methods don't provide relief from your constipation, your doctor may consider adjusting your semaglutide dose

The key anti-oxidative transcription factor, nuclear factor E2 related factor 2 (Nrf2 or NFE2L2), plays a dominant role in defense machinery by reprogramming the iron, intermediate, and glutathione peroxidase 4 (GPX4)-related network and the antioxidant system to attenuate ferroptosis