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Key Findings (20-year risks in early-onset AF vs matched controls): Stroke: 6.9% | 2x higher risk Heart Failure: 6.5% | 45x higher risk Death: 7.1% | 1.4x higher risk Take-home message: Even in the absence of traditional comorbidities, early-onset AF is a marker of future cardiovascular complicationsespecially cardiomyopathy and HF

Purpose-built for physicians Unequivocally yes: MASH therapies still needed despite boom in GLP-1 use in liver disease Although use of glucagon-like peptide-1 agonists for diabetes and weight loss has soared with indications now expanding into liver diseases, specifically metabolic dysfunction-associated steatohepatitis, the jury is still out on its benefit