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All animals were clinically healthy and free from reproductive disorders

25 Most patients die from infections and multiorgan failure, and treatment is centered on supportive care with adjunctive corticosteroids and/or intravenous immunoglobulin (IVIG) therapy

Besides this main action, carnitine has other physiological roles, namely detoxification of non metabolizable acyl residues, general buffering of the acylCoA to CoA ratio, and the shuttling of the acyl groups of acylCoAs, such as peroxisomes, cytosol and mitochondria

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Future studies are needed to further elucidate the underlying mechanisms and validate our findings in larger multicenter cohorts