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Overexpression of the selenoprotein H ( SELENOH ) gene in murine hippocampal HT22 neuronal cells resulted in greater levels of the master regulator of mitochondrial biogenesis, peroxisome proliferator-activated receptor- coactivator-1 alpha (PGC-1), as well as nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (Tfam) within the nuclear fraction compared to vector-transfected cells [Figure 2 ( SELENOH overexpressed cells

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