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Source: Arrone, et al New England J of Medicine May 11, 2025 Researchers randomized about 1,500 people with obesity and without diabetes to be treated with either tirzepatide or semaglutide, both at the highest tolerable recommended doses, and followed them for 72 weeks

Safety and tolerability of glucagon-like peptide-1 receptor agonists: A state-of-the-art narrative review

Id been over 200 pounds (around 233) for a few years, without any luck of shaking it through exercise or diet changes

Yes, vegans require regular B12 supplementation or fortified foods, as vitamin B12 is naturally present almost exclusively in animal-derived products

[4] [5] How Long Diarrhoea Typically Lasts on Retatrutide Diarrhoea is most pronounced during dose escalation and may begin to settle within one to two weeks of reaching a stable dose, though this estimate is based on class experience rather than retatrutide-specific data