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GLP-1 receptor agonists work by mimicking the naturally occurring incretin hormone GLP-1, which enhances glucose-dependent insulin secretion, suppresses glucagon release, and slows gastric emptying

However, participants on semaglutide drank much less, with a higher proportion of zero heavy drinking days than those on placebo

Satiety, clinical adiposity - liraglutide evidence in individuals w, without diabetes study g: Liraglutide and cardiovascular outcomes in adults with overweight or obesity: a post hoc analysis from SCALE randomized controlled trials

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Just as hypertension is rarely managed optimally with a single mechanism of action, complex metabolic dysfunction requires a multi-targeted approach