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This is typically when the most significant body composition changes become apparent

Wegovy (semaglutide) can now be offered to patients at risk of stroke or heart attack, under new guidance issued by the National Institute for health and Care Excellence (NICE)

This has not been tested in a dedicated maintenance RCT, but the dose-response data from STEP-2 (semaglutide 1.0 mg in T2D, Lancet 2021) showing 9.6% weight loss at 68 weeks [13] and SURMOUNT-1 showing 15.0% for tirzepatide 5 mg [7] suggest these lower doses are not inert

This causes your weight to fluctuate, which can eventually damage your metabolism

Eli Lillys revenue rose 32 percent, driven by sales of Mounjaro and Zepbound