Especially, the Kelch-like ECH-associated protein (Keap1) /Nrf2/HO-1 signaling pathway plays a central regulatory role in maintaining homeostasis ( 3.3.3 GPX4-independent ferroptosis pathways In addition to GPX4-dependent antioxidant system in ferroptosis, so far there are alternative identified ferroptosis pathways, including ferroptosis suppressor protein 1(FSP1)/coenzyme Q10 (Co Q10) ( 3.4 Other regulatory mechanisms of ferroptosis There are several classical signaling pathways, which either synergize with ferroptosis or act as upstream regulatory signals that influence cancer cell survival and proliferation, including PI3K/Akt, Wnt/-catenin, p53, ACSL4, Caspase-1-dependent pyroptosis, and AMP-activated protein kinase (AMPK)/ Beclin1 (BECN1) signal pathways
See PRECAUTIONS.
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A total of 115 pathways were identified via the KEGG enrichment pathway analysis, including the HIF 1 signaling pathway, thyroid hormone signaling pathway, hepatitis B, Kaposi sarcoma associated herpesvirus infection, proteoglycans in cancer, renal cell carcinoma, PD L1 expression and PD 1 checkpoint pathway in cancer, Yersinia infection, influenza A, tuberculosis, neutrophil extracellular trap formation, viral carcinogenesis, lipid and atherosclerosis, vascular endothelial growth factor (VEGF) signaling pathway, chemical carcinogenesis-reactive oxygen species, shigellosis, prolactin signaling pathway, central carbon metabolism in cancer, adherens junction, EGFR tyrosine kinase inhibitor resistance, ErbB signaling pathway, prostate cancer, endocrine resistance, choline metabolism in cancer, Chagas disease, Toll like receptor signaling pathway, Ctype lectin receptor signaling pathway, growth hormone synthesis, secretion and action, platelet activation, and relaxin signaling pathway (Fig
