63 Clinicians may wish to consider reducing the dose of insulin secretagogue or insulin to reduce the risk of hypoglycaemia
By looking at the bigger picture, your doctor can help identify whether semaglutide is the likely cause of your leg cramps or if something else may be contributing
Similarly, tapering off the medication can help reduce sudden physiological changes, such as blood sugar level spikes
Metformin, a commonly prescribed diabetes medication, can independently cause diarrhea, and the combination with semaglutide may affect symptoms
In attempts to prolong the half-life of GLP-1 and develop a suitable compound for therapeutic use, some pharmaceutical companies (32) chose to optimize the exendin-4 peptide (a naturally occurring peptide obtained from Heloderma lizard venom, with 53% homology to human GLP-1), which leads to an intravenous half-life of ~30 min (3335)