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Its intracellular depletion ultimately results in cell death, and its clinical relevance has been researched for decades

However, MPs and NPs inhibit production of antioxidant enzyme transcription factors or decrease activity of antioxidant enzymes, which in turn inhibits ROS metabolism and increases mitochondrial membrane potential resulting in an increase in mitochondrial permeability and ROS production, thus increasing mitochondrial ROS production

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Dosages ranging from 1-3 grams appear to hold the most benefits for an individual

Ferritinophagy can also be induced by cystine deprivation that ultimately leads to ferroptosis [134], a mechanism that we have studied extensively in numerous cancer cell types via manipulation of cystine transport mechanisms [135, 136]