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In more than 20,000 patient-years exposure to metformin in clinical trials, there were no reports of lactic acidosis

In the trial with semaglutide 1 mg and 2 mg injection for type 2 diabetes mellitus, GI events occurred more frequently among patients receiving semaglutide 2 mg injection (34%) compared to semaglutide 1 mg injection (30.8%)

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Se observaron pocos episodios (0.1% de los sujetos, 0.001 episodios/aos-paciente) al administrar semaglutida en combinacin con antidiabticos orales distintos de las sulfonilureas