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By injecting subcutaneously near the ankle, the hypothesis is that the peptide can more easily permeate the surrounding tissues and reach the damaged structures

This is especially true with long-term or repeated use of pain medications, where short-term relief can mask progressive systemic side effects

10.1016/J.FITOTE.2011.10.001 133 YangC

The suggestion is that reduced GR activity and therefore less 'reduced glutathione' may be implicated in Irritable Bowel Syndrome - possibly because it has less defenses against free radicals, the cause of oxidative stress

Cattaneo A, Cattane N, Galluzzi S, Provasi S, Lopizzo N, Festari C, et al