Additionally, there are limitations in current clinical trial endpoints, like categorical fibrosis staging in assessing treatment effectiveness
In this population, GLP-1 medications are generally safe, but baseline metabolic rate is already elevated, and the combination requires skilled medical oversight
A large JAMA Surgery study found that over 2 years, mean total costs were higher for GLP-1 receptor agonists than for metabolic/bariatric surgery: about $63,483 for GLP-1 therapy vs $51,794 for surgery
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