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They were absolutely three alarming complications, but then we have enough evidence on all three to believe that we really do not have increased risk of any of them. However, one organ that has been affected by GLP-1 agonists in randomized trials is the gallbladder (7)

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Q2 2024: AstraZeneca and Eccogene announce partnership to develop next-generation oral GLP-1 agonists AstraZeneca entered a strategic partnership with Eccogene to co-develop and commercialize novel oral GLP-1 receptor agonists for type 2 diabetes and obesity, with upfront and milestone payments disclosed

J Biol Chem 2002;277:33895-900

6A) and equivalent -EC yield, 98%, were obtained after 48 h (Fig