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Activation of GPR41 increases the secretion of intestinal peptide YY (PYY) and decreases the secretion of glucose-dependent insulin-releasing polypeptide (GIP) and growth hormone-releasing peptide, thereby reducing glucose uptake (Hu et al., 2018)

Nature (2013) 496(7444):23842

Making the right choice between these medications, when retatrutide eventually becomes available, will depend on individual circumstances, risk tolerance, and clinical needs