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60 To have both targeting therapy and imaging of hepatoma carcinoma cells simultaneously, cyclic arginyl-glycyl-aspartic acid (cRGD) and chitosan as a targeting moiety (RC) were conjugated and so coated on DOX-loaded GO as a drug carrier to form RC-GO-DOX (Figure 1)

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Acknowledgements This study was performed with the support of the National Natural Science Foundation of China (82002339, 81820108020), Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System (BJ1-9000-22-4002)