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The cost of GLP-1 treatment at Nouveau MedSpas generally starts at $450 per month

Additional risk factors include: Type 2 diabetes with impaired counter-regulatory responses long-standing diabetes may blunt the body's natural protective mechanisms against hypoglycaemia Renal impairment reduced kidney function can affect drug clearance and alter glucose homeostasis, particularly if on insulin or sulphonylureas Hepatic dysfunction the liver plays a central role in glucose production and metabolism Excessive caloric restriction very low-calorie diets combined with Wegovy may precipitate symptoms mimicking hypoglycaemia Increased physical activity particularly unplanned or intense exercise without adequate carbohydrate intake Alcohol consumption alcohol inhibits hepatic glucose production and can mask hypoglycaemia symptoms Elderly patients may have reduced awareness of hypoglycaemic symptoms and altered drug metabolism According to the Wegovy SmPC, patients with type 1 diabetes should not use Wegovy , as it is not licensed for this indication and the complex insulin requirements make management challenging

The jury is also still out on certain side effects and on whether patients must continue taking the drugs in a long-term regimen, which would also balloon costs given the already high prices

No prospective pharmacokinetic interaction studies exist for DOAC-plus-GLP-1-RA combinations

Natural GLP-1 activation works differently