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While the relevance of these findings to humans remains uncertain, the potential risk necessitates avoiding tirzepatide in patients with known susceptibility to these rare thyroid malignancies

Causality is not proven, but chronic daily use should be minimized

14 Recommendations The results above have prompted the ADA and EASD to recommend GLP-1RAs as preferred second- or third-line injectable agents following metformin in people with: 1 established atherosclerotic cardiovascular disease a need to minimise weight gain or promote weight loss a need to minimise hypoglycaemia mild-to-moderate chronic kidney disease

It reduces blood volume, forcing your heart to work harder to pump oxygen and nutrients to your muscles and brain

J., Kulkarni, S