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The resulting increase in free copper exacerbates oxidative stress and proteotoxicity, further depleting GSH pools and impairing its metal-binding capacity [111, 112]

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Fisher A, Pittel Z, Haring R, Bar-Ner N, Kliger-Spatz M, Natan N, Egozi I, Sonego H, Marcovitch I and Brandeis R (2003) Ml muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy

The show received mixed reviews but had a successful launch week, debuting at number one

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