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It is worth mentioning that most of the above-mentioned mechanistic studies were performed using isolated organelles and high concentrations of the drug and that such experimental in vitro conditions might not always reflect the physiological in situ environment

0.9% at 12 months, p = 0.000)

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The pancreas was infused with 0.25 mg/ml collagenase (Sigma-Aldrich) for 40 min to obtain a single cell population

Or 5 mg