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Reactive processes associated with it result in the release of inflammatory mediators, including reactive oxygen species, which travel from the brain to the heart or vice versa, serving as key ambassadors of intercommunication and cellular destruction

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More specifically speaking, GLP-1 receptor activation facilitates the presynaptic release of GABA into RGCs via the Gs/cAMP/PKA/Phospholipase C (PLC)/IP3/Ca2+/CaM signaling pathway, ultimately increasing the GABAergic miniature inhibitory postsynaptic currents (m-IPSCs) frequency and contrast sensitivity ( The GABAergic modulation ability of GLP-1RAs is more thoroughly studied in brain tissues and cells

& Norjavaara, E

2023;25(11):e3550