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However, this massive gray-market loophole has allowed an explosion of underground wellness clinics, cosmetic spas, and fitness influencers to actively, and illegally, market these unregulated injectables for therapeutic use

The reference method to assess IAH is the hyperinsulinaemichypoglycaemic clamp [115], although this is not used out of a research frame due to its invasiveness, cost and time commitment from people with diabetes

Current clinical practice guidelines from organizations such as the American Association of Clinical Endocrinology (AACE), the Endocrine Society, and the American Diabetes Association (ADA) support long-term use of anti-obesity medications when clinically indicated

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