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After taking a look at current research, the European Medicines Agency said NAION may affect up to 1 in 10,000 people taking semaglutide

Treatment history and rationale guide decision-making

Excess body weight and gastroesophageal reflux disease

Compounded semaglutide is a synthetic glucagon-like peptide-1 (GLP-1) receptor agonist used for chronic weight management, along with a reduced calorie diet and increased physical activity, for people with an initial body mass index (BMI) of: 30 kg/m2 or greater (obesity) or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e.g., hypertension, type 2 diabetes mellitus, or dyslipidemia)

Denters for Disease Control and Prevention, Childhood Obesity Facts, Obesity (2024)