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Even when not covered, they are typically available at relatively low cash prices

A guide for medicinal chemists and pharmacologists

The more recent SELECT trial, published in the New England Journal of Medicine in 2023 and highlighted by the American Heart Association, showed a 20% reduction in major cardiovascular events in patients with overweight or obesity and pre-existing cardiovascular disease but without diabetes

The compound acts as a biological switch rather than a sustained agonist

The removal triggered a wind-down period during which compounding pharmacies could continue to produce tirzepatide for existing patients but were required to cease new compounding after the period ended