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doi: 10.1111/jgh.15899 169 SinghMPChoHJKimJ-TBaekKELeeHGKangSC

FOXO4-DRI has a rapidly expanding and high-impact published research base, with studies published across Nature, Nature Communications, Communications Biology, Aging, Frontiers in Bioengineering and Biotechnology, and PMC since its foundational description in 2017

However, it is plausible that the heightened risk of neurodegeneration associated with ranibizumab may primarily affect individuals already predisposed to such side effects due to underlying factors like a family history of PD or AD, or the presence of uncompensated diabetes (Sultana and Scondotto 2020

FDA requires consistent, high-quality evidence