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Receptor saturation studies show that GLP-1R and GIP-R activation follows a dose-response curve with diminishing marginal benefitmeaning that adding more receptor stimulation beyond a certain threshold generates side effects without proportional weight loss gains

Kim YJ, Han JH, Kang HY, et al

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The pharma company Amgen, which manufactures Enbrel, sued, arguing that the cap undermines federal patent law and would cause the company economic harm