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Consequently, the contribution of xCT to cancer cell growth may be overestimated, whereas the importance of GGTs may be undervalued

Starting with lower doses and gradually titrating upwards, as recommended in prescribing guidelines, can help minimise gastrointestinal symptoms

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An inhibitory role of vitamin K in HCC development has been reported in preclinical models (107, 108), and it is currently being studied as a potential cancer chemosensitizer in combination with other oncologic drugs (109)