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Further in-depth pharmacokinetic studies on humans and toxicology research, the mechanism of combination therapy, and research on new CHE-based biomaterials for reducing drug toxicity and structurally optimized analogs are required to enhance the efficacy and safety of CHE, and more clinical studies are required in the future to validate preclinical studies of CHE as an antitumor strategy

Even without intrinsic factor, a small amount of B12 can still be absorbed through passive diffusion