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Increased production of nitric oxide (NO), via endothelial NO synthase (eNOS), is elicited by estrogen, shear stress, vascular endothelial growth factor, or other mechanisms in ECs ( + channel-dependent hyperpolarization is an important contributor to the reduced UtA vascular tone and increased diameter observed during pregnancy ( 1.3 Impairments in vascular adaptations during pregnancy Appropriately timed pregnancy-dependent changes in vasculature are critical for healthy pregnancy outcomes

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[DOI] [PubMed] [Google Scholar] [137].Zhu K, Kakkar R, Chahal D, Yoshida EM, Hussaini T