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They may be considered as part of dual or triple therapy when specific criteria are met, including BMI thresholds (35 kg/m or 32.5 kg/m in certain ethnic groups) and when weight loss would benefit other obesity-related comorbidities

85,87 A multicenter study of a proprietary peptide blend reformulated with octapeptide-45 and magnolol demonstrated significant improvements in collagen, elastin, hyaluronic acid (HA), and adipocyte maturation as evidenced by increased proportion of perilipin-1 staining

Competing Interests The authors have no conflicts of interest to declare

Treatments options Outpatient therapy Inpatient rehab therapy Psychotherapy Medication Complementary therapies "It's not one-size fits all," Ashton explained