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Common Side Effects When side effects occurred, they were typically mild, transient, and similar in frequency to placebo groups: Reported Adverse Effects Most Common (occurring in small percentage of participants): Mild to moderate headaches (most frequently reported, often resolving with continued use) Injection site reactions (minor redness, swelling, or irritation at injection site) Gastrointestinal effects (particularly at higher oral doses: mild nausea, diarrhea, flatulence) Fatigue (reported occasionally during initial adaptation period) Rare Events: One case of chest tightness was deemed possibly related to treatment in safety trials

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16 weeks (1x daily, 5-on/2-off) 4 vials 80 doses needed

MT can localize to the intermembrane space, where its N-terminal -domain delivers zinc to components of the electron transport chain, modulating respiration in a zinc-dependent and tissue-specific manner 89