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It is a life-threatening condition that occurs as a result of pathologically high levels of skeletal muscle contraction from increased intracellular calcium that occurs in the absence of neuromuscular stimulation

Neuroscience 137:80719, PMID: 16330153 Abramov AY, Canevari L, Duchen MR (2003) Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity

Toborek et al, 1995

In addition to these metabolic and nutritional pathways, gut microbiota dysbiosis also influences neuroendocrine regulatory mechanisms through modulation of neurotransmitter synthesis