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Human germline mutations in glutarate metabolism highlight its fundamental biological role, with loss of function mutations in glutaryl-CoA dehydrogenase (GCDH) resulting in glutarate accumulation and glutaric aciduria type 1 (GA1)a rare autosomal disorder characterized by dystonia, developmental delay and often death in early childhood 10

The key organs that support detoxification pathways include the liver, kidneys, and skin, as well as the respiratory (lungs), lymphatic, and digestive systems

Thus, it required a subsequent purification to remove the inactive D-isomer

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The lack of body fat stores loss may be explained by the 18% increase in body fat mass associated with CHO supplementation alone, noted in the control group [6]