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Patients enrolled in the trial had biopsy proven NASH/borderline NASH (NAS 4) without cirrhosis (n = 283)

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A study indicated that exenatide significantly reduced fMRI alcohol cue reactivity in key brain regions, such as the ventral striatum and septal area, which are important for drug reward and addiction-regions with high GLP-1 receptor expression

Moreover, SLC7A11 and cyclin-dependent kinase inhibitor 1A (CDKN1A) gene expression is stimulated by the p53DPP4 interaction, thereby inhibiting ferroptosis (82)