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The Medicines and Healthcare products Regulatory Agency has not approved it for any clinical use, and it cannot lawfully be marketed for human consumption, sold as a supplement, or prescribed on the NHS

Cystine uptake determined the sensitivity of acute myeloid leukemia cells to APR-246 Since cysteine is a biosynthetic precursor of GSH, we asked whether the ability of cells to provide cysteine for GSH synthesis underlies the sensitivity to APR-246

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revealed that the use of a novel REDOX selective APE1 inhibitor in vitro and in vivo could effectively reduce the progression of bladder cancer, and the combination of this inhibitor with cisplatin, a commonly used chemotherapy drug, was more effective than cisplatin alone [26]