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Inhibiting thioredoxin (TRX) with PX-12 could blunt the protective effect of silencing TXNIP in hypertension, suggesting that PX-12 disrupted the balance of the Trx system [61]

In follow-up of these studies, it was shown that Mito-TEMPO, which is highly effective in protecting against APAP toxicity [29], did not reduce LPO or liver injury in animals co-treated with APAP and Fe 2+ [82]