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Mechanistically, activation of GLP-1R by GLP-1 or exenatide phosphorylates STAT3, which drives human monocyte-derived macrophages to develop an M2 phenotype marked by increased expression of CD163, CD204, and IL-10 [86]
In 2023, a Prime Therapeutics analysis revealed that 6.8% of individuals discontinued a popular anti-obesity medication due to side effects in clinical trials, and only 33% continued use after one year, according to a Reuters report
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