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In extreme cases, people with pernicious anemia or a related condition known as vitamin B12 deficiency myelopathy can develop nerve damage related to vitamin B12 deficiency
Vitamin B12 interactions [Moderate interactions, but CRITICAL] Important notes: - Regarding the first interaction (metformin and vitamin B12), here is the reference & the exact text that mentioned the using of calcium supplements: #Katzungs #basic_and_clinical_pharmacology, 16th edition, chapter 41 pancreatic hormones & glucose-lowering drugs, page 798: metformin interferes with calcium-dependent absorption of vitamin B12-intrinsic factor complex in the terminal ileum, and vitamin B12 deficiency can occur after many years of metformin use
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