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This is one of the most common questions our clinic receives, and it is a fair one

However, regulatory decisions are based on comprehensive reviews of clinical data, manufacturing information, and safety assessments

Severe hepatic impairment lacks adequate safety data, making tirzepatide use in these patients rely on careful individual benefit risk assessment

doi: 10.1038/s41598-017-15668-z 61 YeePPWeiYKimSYLuTChihSYLawsonCet al