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For example, curcumin in nanoformulation and liposomal encapsulated has been investigated to circumvent poor systemic absorption and enhance targeting into tumour tissue to permit accurate discovery of dose-response relationship as well as pharmacodynamic effects in vivo (229)

Complex intervals can create unwanted dissonance and a"muddy"sound when amplified, but the pure interval of a perfect fifth in a power chord allows it to cut through the mix with clarity and force

As present in Table 2, five ML models showed moderate performance under the Borderline-SMOTE approach, with AUC values ranging from 0.642 0.073 (DT) to 0.870 0.022 (LR), but struggled with recall, as seen in models like RF (0.099 0.073), KNN (0.124 0.048), which achieved high accuracy but low recall, indicating challenges in handling imbalanced data

Nat Chem Biol 7 , 101105 (2011)

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