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25,36 In contrast, replacement with Glu increased both the affinity and activity to some degree

10.1002/brb3.2177 245 KobayashiY.SugaharaH.ShimadaK.MitsuyamaE.KuharaT.YasuokaA.et al

This shift in perspective also opens new challenges for computational and experimental drug discovery

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Other GLP-1 receptor agonists include semaglutide (Wegovy for weight management, Ozempic for diabetes) and liraglutide (Saxenda for weight management, Victoza for diabetes), with semaglutide 2.4 mg demonstrating greater average weight loss than liraglutide 3.0 mg in clinical trials